I have this type of door on my Cabin and I love the look...just so happened that the house I moved in to has the same type...the window was missing, I've put in some glass but I was wondering if I can still find the window grill anywhere? It's a fairly common door style and I'm just hoping it's available somewhere....
Source: http://www.houserepairtalk.com/f10/looking-window-grill-15487/
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Obesity and its related conditions such as type 2 diabetes, cardiovascular disease and stroke are among the most challenging of today's healthcare concerns.
Together, they constitute the biggest killer in western society. New findings, published in Cell, have identified a target that could hold the key to developing safe therapies to treat obesity and its associated conditions.
Although recent research has begun to unravel some of the pathways that control how information is processed by our nervous system regulating body weight and cardiovascular function, the exact mechanisms through which signals are sensed by the brain and translated into co-ordinated metabolic and cardiovascular responses remain unclear.
A University of Bristol team, with funding from the British Heart Foundation (BHF), has now identified that a target found to be critical in the brain's regulation of body weight, is also crucially involved in the development of obesity-associated conditions. Researchers describe the mechanism behind a key molecule, known as melanocortin-4-receptor (MC4R), whose mutation or loss in both human and animal models has shown to cause severe obesity with type 2 diabetes.
While previous studies have shown that small activators of the molecule, which increase MC4R activity, have the desirable effect of reducing food intake and insulin secretion from the pancreas (important to suppress the development of type 2 diabetes), it is not clear how, at the same time, they trigger the undesirable effect of increasing blood pressure.
The team has now identified a mechanism for MC4R-mediated regulation of the activity of the autonomic nervous system to maintain appropriate blood pressure and insulin levels. The autonomic nervous system, which regulates internal organs and processes that are not under our control, is split into the parasympathetic and sympathetic nervous system, commonly exerting opposing influences on the structures they supply with nerves.
Researchers demonstrated that the activation of the MC4R inhibits parasympathetic neurons in the brain stem area of the central nervous system (CNS), while activating sympathetic neurons in the spinal cord. The team further demonstrates, in genetically-modified mouse models of human loss of MC4R function, that MC4Rs in these CNS areas are to blame for the development of obesity-induced increases in blood pressure.
They also report that MC4Rs in these CNS areas are pivotal in maintaining appropriate insulin levels to stave off type 2 diabetes. Thus, by carefully balancing positive and negative forces on the autonomic nervous system, the MC4R maintains equilibrium of appropriate blood pressure and insulin levels. This is independent of the MC4R's role in the regulation of food intake elsewhere in the CNS.
MC4R is a target of intense pharmaceutical interest and the data from this research helps in our understanding of the CNS mechanisms regulating homeostatic body weight, blood pressure and insulin levels through a distributed network of MC4Rs. These findings may facilitate the development of appropriate, safe therapies to treat obesity and its associated conditions.
Dr Nina Balthasar, one of the study's lead authors and a researcher in the University's School of Physiology and Pharmacology, said: "Obesity is a major risk factor for cardiovascular disease with recent statistics showing that obese adults are three to four times more likely to develop high blood pressure.
"In order to curb the escalating incidence of obesity and obesity-related diseases, a primary prevention goal must be to understand the physiological processes underlying our vulnerability to weight gain ? knowledge that is central to the development of novel, effective therapies.
Our data illustrate the complexity of the CNS pathways governing the body's metabolic balance and highlight the challenges ahead for the development of safe therapies. "
Dr Shannon Amoils, Research Advisor at the BHF, which part-funded the study, added: "This research increases our understanding of how the nervous system affects our metabolism, and the development of high blood pressure due to obesity. With further knowledge of this complex area we hope scientists will be able to find safe and effective ways of treating obesity-related heart and circulatory disorders."
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University of Bristol: http://www.bristol.ac.uk
Thanks to University of Bristol for this article.
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Woz designed the hardware, circuit boards and operating system for the Apple I.
Woz took his pet project to HP and "begged" them to manufacture the PC, he told Georgia State University students on Wednesday.
"Five times they turned me down," the Atlanta Business Chronicle?quotes?Wozniak from his lecture.
When Steve Jobs saw the Apple I, he recognized its potential.
Jobs didn't say, "Oh my gosh, let's start a computer company," Wozniak recalls. "He said, "Let's start a company to build one little part ? a printed circuit board, so people can assemble a computer. Let's build it for $20 and sell it for $40."
Woz believes that even if he and Jobs didn't form Apple, his products still would have influenced the world.
But he says that he might not have started a company because he's not the risk-taking type of?entrepreneur.
Poor choice by HP in hindsight.
Don't miss: 10 Mind-Blowing Projects Made With A Tiny $35 Computer
Source: http://www.businessinsider.com/woz-begged-hp-to-make-the-apple-pc-2013-2
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Ewan McGregor as Elmont in "Jack the Giant Slayer"
Credit: Warner Bros. Pictures
The retelling of a classic fairytale ? one as famous and re-trod as Jack and the Beanstalk ? is that it can get an update or a flourish with each redux. Or in the case of ?Jack the Giant Slayer,? a stylistic twist. Ewan McGregor is a representative sample of the notion, in part, because: just look at that hair-do.
It?s not that the physical evolution of the star from ?Trainspotting,? ?Moulin Rouge? and ?The Impossible? into Top Dog in the King?s guard in the ?Giant? movie is all that revolutionary. McGregor?s character Elmont?s cowlick is a mile-high and his battle armor is form-fitting and slick, a dandy by all standards. Even as slipped from the idyllic set of ?Jack the Giant Slayer? to discuss his role with a group of us journalists, he strode into the room with a swagger.
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From where did a fashionable, horse-riding pretty boy military presence grow from the original ?Beanstalk? story? The answer is from director Bryan Singer?s want for style, as evident from his ?X-Men? movies, and his esteemed filmmaking army spinning humor out of this yarn (because what?s a dimple-chinned macho man without his funny faults?).?
McGregor, lead Nicholas Hoult, Stanley Tucci, Bill Nighy, Ian McShane and other able-bodied vets round out this reimagining, with the ?imagining? playing a central role to their performances: as CGI creations with the help of motion-capture, the unseen, malevolent forces, were built-out in post-production, thus the actors worked their wares without them in place.
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Below, McGregor talks about that process, and what it takes to become a pastry, and exactly what he thinks of pre-vis (hint: not a fan).
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What first attracted you to the role?
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Ewan McGregor: I liked the script. I was sent the script and I was probably a little dubious about it, to be honest. I didn?t know quite what I thought about trying to retell a classic fairytale. I kind of approached the script feeling a bit like, ?Well, I?m not going to like this.? But I did! I really liked the script. I liked the humor in the script. The characters in it were strong. In a film that?s this technologically based, I think that?s really important that you have clear and well-identifiable characters. I felt that that was the case.
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And then it reminded me a bit of that film "How to Train Your Dragon." I love the feeling of that film and the humor in it. This felt somewhat similar to that. I?m not sure that it?s become that, I?m not sure how much of that humor we?ve captured or not, because it?s impossible on a film that takes this long to shoot?we?ve been shooting for five months, really.
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It?s like a jigsaw film. There?s the work that we do and then there?s many, many other elements, where in other films, you shoot the scenes and that?s what ends up being the film. Of course that can change with editing and music, but on a film like this, there are so many other elements, like the giants and the motion capture capturing the giant?s movements, turning the giants into real giants?our interaction is all the unknown, really. They?ve certainly got enough footage to cut it any which way. But until I see it, I don?t know how much of that humor?s survived.
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What?s your character like? Is he the comic relief of the crew? What does he do?
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I don?t think he?s the comic relief. I liked him because he?s very gung-ho. He?s always the one that?s saying, ?Come on, let?s go!? But very often not succeeding very well in what he?s trying to do and then Jack steps in and saves the day. I like that, kind of comic element of him, if you like.
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At the same time, he is the leader of the Guardians. He?s in charge of them, and that was fun to play. I haven?t done that before, playing the top military guy. I have done a military film before, but it was fun to be in charge.
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What?s his relationship with Jack? Does he welcome him with open arms?
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No, he?s a bit dubious about Jack to begin with, I think. My character?s main job is to look after the princess, during peacetime, that?s my main lookout. It strikes me, and I?ve never discussed it with anyone, but the Guardians are the kind of royal soldiers, the top knights. But during the peacetime at the beginning of the film they?re in charge of the security and safety of the royal family, so myself and Eddie Marsan?s character, it seems that we are in charge of looking after Isabelle [Eleanor Tomlinson], the princess. She?s a very reluctant princess and she?s always trying to slip off into the kingdom and have a life and not feel like she?s?she wants her freedom, in a way. She?s a bit of a reluctant princess. So she?s quite difficult to look after.
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And so my first encounter with Jack is when she?s given us the slip. We find her at this?at the beginning of the film, there?s a pantomime going on about this fable of the giants who live in the sky. And it was really nicely put together by Warwick (Davis) who has an agency of small and very big people, so he used all his actors and he directed this pantomime that we shot in this lovely, old circus tent. So we find Isabelle there, she?s watching the show. At that point, when we come into the tent, everyone bows down because we represent the king, except for Jack, who doesn?t bow down because he?s taken by surprise.
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So my first introduction to him is that he?s somebody who?s not very respectful to us and I?m a bit dubious about what he?s after with the princess, as well. But as the story unfolds and as Jack?once the beanstalk has appeared and the princess has disappeared, he comes along with us, with the Guardians, the kind of search party for her. Slowly, he keeps proving himself over and over.
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What specific things did you have to do to train for this film?
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Mainly we did horse riding. Stanley Tucci and myself have a fight in the film, so we would ride for an hour or two and then we?d work on the fight. For three weeks, that was our rehearsal block. We never got allowed to ride a horse in the film; we just got to sit on them. So it was just kind of a waste of everybody?s time.
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Do you sing in this?
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Nope.
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Do you want to?
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Yeah! I think it would be a big improvement. I could sing now, but it doesn?t feel quite right in here. But it would be nice to have a little song somewhere along the line, maybe climbing the beanstalk. He?s the kinda guy who might break into song at any moment, Elmont. You should suggest it to the director if you speak to him. When we come back for the re-shoots in October, I?ll do it then.
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Talk a little bit about working with the 3D cameras and, as an actor, what is that like? I know it slows things down a little.
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I don?t think it?s as slow as people think. This film has been very slow, but I couldn?t blame the 3D for it. Early on maybe there was more problems with it. Though sometimes there are problems because each camera is, in fact, two cameras and sometimes the 3D, like one eye will go out. I don?t pretend to understand it all completely, but each camera represents our eyes so it?s a slightly different angle on the scene. They have to play with the perspective of that, so there?s the focus but also the convergence, I think it?s called. Occasionally, one of the eyes will go out, but really not that much. I haven?t found it to be that slow. In actual fact, that seems to be the nature of it.
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Again, I?ve never discussed this with anyone, but it seems to me that we do less coverage on a scene. The 3D has more of a sense of everybody in the scene, so if there?s a shot with 4 or 5 people in it, you?re already sort of in your own shot because of the 3D feel. It seems to me that we?ve had less close-ups and less coverage. So if this 3D is slower, which I don?t think it is really, then we save time with the lack of coverage.
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How is it working with the CGI, with the giants that aren?t actually there?
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I?ve done a lot of it in the past, so it?s not something that is new to me, really. It?s a skill like any other. You know what the scene is about and you know where your character is and what he?s thinking and feeling, so it?s not really a problem. I think when you get into those scenes, from what I?ve seen of the little bit that?s been put together, what they?re grabbing from our takes is just a little tiny snatch here and the giant there. It?s an editing job, really. There haven?t been any moments that have been really difficult.
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There are only a very few moments when we actually are physically interacting with each other. There are a couple of moments when I?m picked up and I?m carried upside down by the giant and then laid down on the floor. So the picking up and the laying down we did with the harness and cables. There?s another moment where a giant rolls me in pastry to put me in the oven. The actual rolling in pastry was a technical challenge for the special effects team. They made a body mold of me and then made the back mold that I could lie in and then the front mold clamped over me, Velcroed over me, so I was held in place on an arm. Then, that was lowered onto the pastry. As the giant rolls me over like this, the rig rolled over and then the pastry wrapped around me. So that was more for the special effects people who did a really good job.
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In this film, we have the technical ability to match the motion capture stuff that they?ve done of the giants before. They can overlay them onto the same frame that they?re seeing live from the camera. They can actually frame up on the giant. So if there?s a shot of the giant over my shoulder, they can literally put the camera looking over my shoulder and they can see where the best place is because they can see where the giant?s going to be. That?s quite new, I think.
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There?s a lot of pre-vis in this movie, if not the whole movie?s been pre-vis. Can you talk about, as an actor, doing your own performance while still having to hit the pre-vis or working with those two kinds of environments?
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Yeah. It?s very rare that we have to match to the pre-vis, but it does happen now and again. It usually just ends with me getting really pissed off and telling him to f*ck off. For instance, there was a moment when I had to stab a giant in the leg and I was stabbing the giant in the leg in the way that I wanted to stab the giant in the leg. Then I was directed to do it with two hands because the guy in the pre-vis does it with two hands. And I said, ?Well, you should have paid the guy in the pre-vis to play Elmont and not me, then.??Because a guy in L.A., I guess, an animator?it should just be a kind of template for what?s to happen.
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But it?s very rare you get directed to match the very wobbly animation from the pre-vis. I can give them that performance if they want. But I don?t think they?d be happy.
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Source: http://www.rottentomatoes.com/m/1926762/news/1926762/
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Cars, debris and outbuildings rest on the property where an eccentric man known simply as Radkin lived in Alburgh, Vt., Friday, Feb. 1, 2013. It took months for anyone to discover that Radkin had died in an accident on his land. But four people ? Mark Mumley, Shawn Farrell, Ricky Benjamin and Jennifer Jarvis ? are facing charges for stealing more than $200,000 in gold coins and other items from the property. (AP Photo/Wilson Ring)
Cars, debris and outbuildings rest on the property where an eccentric man known simply as Radkin lived in Alburgh, Vt., Friday, Feb. 1, 2013. It took months for anyone to discover that Radkin had died in an accident on his land. But four people ? Mark Mumley, Shawn Farrell, Ricky Benjamin and Jennifer Jarvis ? are facing charges for stealing more than $200,000 in gold coins and other items from the property. (AP Photo/Wilson Ring)
In this booking photo released by Vermont State Police, 35year-old Ricky Benjamin of Alburgh, Vt. is seen. Police say more than $200,000 in gold coins were stolen from a vacant home after its eccentric owner died in a farm accident last year. Authorities say four suspects also stole a vehicle, antiques and other items from the home in Alburgh in the months after its owner's death. Benjamin, Mark Mumley, 52, and 41-year-old Shawn Farrell, of Swanton, were arraigned and held on $75,000 bail. (AP Photo/Vermont State Police)
In this booking photo released by Vermont State Police, 52-year-old Mark Mumley, of Alburgh, Vt. is shown. Police say more than $200,000 in gold coins were stolen from a vacant home after its eccentric owner died in a farm accident last year. Authorities say four suspects also stole a vehicle, antiques and other items from the home in Alburgh in the months after its owner's death. Mumley, Ricky Benjamin, 35, and 41-year-old Shawn Farrell, of Swanton, were arraigned and held on $75,000 bail. (AP Photo/Vermont State Police)
In this booking photo released by Vermont State Police, 41-year-old Shawn Farrell, of Swanton, Vt. is seen. Police say more than $200,000 in gold coins were stolen from a vacant home after its eccentric owner died in a farm accident last year. Authorities say four suspects also stole a vehicle, antiques and other items from the home in Alburgh in the months after its owner's death. Farrell, Ricky Benjamin, 35, and Mark Mumley, 52, were arraigned and held on $75,000 bail. A fourth suspect was released after being issued a citation. (AP Photo/Vermont State Police)
This booking photo released by Vermont State Police shows Jennifer Jarvis, 32, of Alburgh, Vt. Authorities said four suspects, including Jarvis, stole items including more than $200,000 in gold coins from a vacant home in Alburgh after its eccentric owner died in a farm accident last year. Jarvis was arrested on Jan. 24, 2013, on charges of burglary and possession and sale of stolen property. (AP Photo/Vermont State Police)
ALBURGH, Vt. (AP) ? It took months for anyone to discover that an eccentric man known simply as Radkin had died, crushed under a tractor-pulled horse trailer on his property on the shores of Lake Champlain in northern Vermont. But it didn't take long for looters to ransack the hoarder's dilapidated house, police say, hauling off antiques, a vehicle, scrap metal and more than $200,000 in gold coins.
Four people, including at least one who police suspect knew the 66-year-old Radkin, are facing charges of stealing the coins and cashing them in at coin and jewelry stores. Police expect to make more arrests.
"We've been watching the looters come and go," said John Fleury of Enosburgh, who has a camp across Route 2 from Radkin's property in Alburgh, which used to belong to the family of Fleury's wife.
He said no one called the police because no one was concerned.
The property includes a dilapidated brick house and outbuildings full to the brim with stuff.
"What it is is a hoarder's house," said Vermont State Police Sgt. Maurice Lamothe, who is investigating the burglaries. "The exterior is covered in outbuildings, cars, trailers and everyone one of them is full, I mean full to the top. I had never been in a hoarder's house prior to this. The rooms, you can't walk through them, you can't walk through any of them."
Charged are Ricky Benjamin, 35, and Mark Mumley, 52, both of Alburgh, and Shawn Farrell, 41, of Swanton, who have significant prior records, Lamothe said. Mumley is being held on $75,000 and Benjamin was released on bail. A fourth suspect ?32-year-old Jennifer Jarvis of Alburgh ? was released after being issued a citation.
Police said Thursday the defendants sold coins ranging in value from $350 to $1,800 to coin and jewelry dealers in another county after allegedly claiming they'd inherited the coins.
But the number of coins coming in was a red flag for one dealer, who called police in September.
So far, investigators say they've recovered $5,000 in coins, which are British sovereign coins.
A friend of Radkin wasn't surprised that he had the coins.
"I'm surprised by how much he had," said Van Powell, mechanical shop manager for the Shelburne Shipyard, where Radkin once worked and adjacent to where he used to live.
"Radkin was inclined to acquire stuff whether he needed it or not. At one point he had five or six MGs, none of them running," he said of the property on Shelburne Point, where Radkin had served as a caretaker. "He had multiple tractors, trucks. He had at least 20 or 30 vehicles; some of them would run, most of them didn't. He had at one point six or seven pianos and he just kept them in the front yard of his house covered with canvasses and I just thought that was odd because he was quite a good musician. He would play the trumpet and the piano."
His house was so full of stuff, a person couldn't really walk through it, Powell said. "You just had to turn sideways," he said.
People either loved Radkin or hated him, he said.
Neighbors had feuded with him in Alburgh, where he had been known to run around his property naked, Fluery said.
"Radkin was very, very rude," he said.
Born Richard A. Burgess in Greenfield, Mass., in 1945, he graduated from Deerfield Academy and later changed his name to just Radkin, and eventually lived as a caretaker on property on Shelburne Point. He worked at Mad River Glen ski area in Fayston at one point. He liked to go to auctions and flea markets and lived off the grid.
"He was an unusual fellow, that's for sure," Powell said.
Radkin had asked the owner of Shelburne Point, a prime piece of land on Lake Champlain, if he could keep his horse there and eventually built a house on wheels and asked if he could keep it there and live it in.
Willard Jackson said he agreed, with some trepidation. "For over 20 years, he was the self-appointed caretaker of Shelburne Point and in the process became a legend," Jackson wrote in an online memorial to Radkin.
Jackson's son said Radkin was told he needed to find another home when the family decided to subdivide the property. He moved 55 miles north to Alburgh, but it took him a number of years to leave the point, moving small amounts at a time, Van Powell said.
When a friend had not heard from or seen Radkin in a while, he called the sheriff's department. His body was found crushed under the trailer last March, in an accident that officials believe happened in December 2011. A memorial gathering was held in Shelburne Point in August.
"He was fiercely independent and, in his later years, lived like a pioneer or as Henry David Thoreau did at Walden Pond. He hardly ever bought anything and was content to make do with what no one else seemed to want. He was a farmer, mechanic, inventor, engineer, philosopher, concerned citizen and loyal friend," Jackson said in his memorial.
The property is now being handled by a lawyer. If the price is right, Fleury would consider buying it.
"I'm thinking I'm going to have quite a remodeling job on my hands," he said.
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Rathke reported from Montpelier, Vt.
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